kompositioner och foerfaranden foer modulering av rna molekylens aktivitet genom modifiering av cap strukturen i rna molekylens 5 '- aenda

摘要

Methods for achieving therapeutic treatment of diseases and for regulating gene expression in biological experimental systems via modification or removal of the 5' Cap structure of targeted ribonucleic acids are disclosed. Modification or removal of the 5' Cap structure is achieved in accordance with preferred embodiments utilizing antisense compounds which are complementary to the 5' terminus of the targeted RNA and have attached to them reactive moieties explicitly designed for chemical modification of or cleavage reactions with the 5' Cap structure of RNA.