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PREPARATIVES CONTAINING AT LEAST ONE OF THE FOLLOWING AGENTS: TRAMADOLE, CODEINE, OXICODONE AND HYDROCODONE AND THEIR APPLICATION
PREPARATIVES CONTAINING AT LEAST ONE OF THE FOLLOWING AGENTS: TRAMADOLE, CODEINE, OXICODONE AND HYDROCODONE AND THEIR APPLICATION
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机译:至少包含以下一种制剂的制剂:曲马多,可待因,二氢可待因酮和氢可酮及其应用
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摘要
This invention relates to compositions comprising a tramadol material and any of codeine, oxycodone or hydrocodone, and their use. The compositions are pharmacologically useful in treating pain, diarrhea and tussive conditions. The compositions are also subject to less side-effects as compared to pure opiate based compositions, such as abuse liability, tolerance, constipation and respiratory depression. Furthermore, where the components, i.e., a tramadol material and any of codeine, oxycodone or hydrocodone, of the compositions are within certain ratios the pharmacological effects of the compositions are superadditive (synergistic). IMAGE
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