PROCESS FOR PRODUCING N-IMIDAZOLYL DERIVATIVES OF SUBSTITUTED ALKOXYIMINO TETRAHYDRONAPHTHALENES AND CHROMANS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS

摘要

The invention provides new imidazole containing alkoxyimino derivatives of tetrahydronaphthalene and chroman of general formula (I) CHEM wherein Z is -CH2-or-O-; m is an integer of 1 to 4; n is zero or 1; T is a straight or branched, saturated or unsaturatrd C1-C6 hydrocarbon chain, or a phenylene radical; A is a bond or a divalent group consisting of-Si(R min R sec )-; -O-CH2-,-CF3-,C(R min R sec )-,vinylene or isopropenylene, wherein each of R min and R sec being the same or different is hydrogen or C1-C4 alkyl; R is hydrogen or C1-C4 alkyl; R1 and R2, being the same, are hydrogen or methyl, or one of R1 and R2 is hydrogen and the other is a) a C1-C8 alkyl group; b) a C5-C8 cycloalkyl or C5-C8 cycloalkyl-C1-C4 alkyl group, wherein the cycloalkyl group or moiety is unsubstituted or substituted by 1 to 4 C1-C4 alkyl groups; or c) an aryl or aryl-C1-C4 alkyl group, wherein the aryl group or the aryl moiety is unsubstituted or substituted by 1 to 4 substituents independently chosen from halogen, hydroxy, C1-C4 alkyl, trihalo-C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio and C1-C4 alkylsulfonyl; R3 is hydrogen or a substituent chosen from halogen, hydroxy, C1-C4 alkyl, trihalo-C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio and C1-C4 alkylsulfonyl; R4 is an -OR5, or -N(R5 R6)group, wherein each of R5 and R6 independently is hydrogen, C1-C6 alkyl, phenyl or benzyl; and the pharmaceutically acceptable salts thereof, which are useful in the treatment of a disease state in which an anhancement of TxA2 synthesis exerts a pathogenic effect.