TYLOSIN RESISTANCE-CONFERRING GENE,DESIGNATED tlrB FOR USE IN STREPTOMYCES AND OTHER ORGANISMS

摘要

The tlrB gene is a novel tylosin resistance-conferring gene isolated from Streptomyces fradiae and used to construct a number of cloning vectors for use in Streptomyces and related organisms. One such cloning vector, plasmid pSVB9, can be obtained in S. lividans under the accession number NRRL 18073. S. lividans is the preferred host when the tlrB gene is used to select tylosin-resistant Streptomyces transformants.