4-(4-(4-(4-((2- (2,4-DIFLUOROPHENYL)-2- (1H-AZOLYLMETHYL)-1,3- DIOXOLAN-4-YL)METHOXY) PHENYL)-1-PIPERAZINYL) PHENYL) TRIAZOLONES, THEIR PREPARATION AND ANTIMICROBIAL COMPOSITIONS CONTAINING THEM

摘要

Novel 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4 -yl] methoxy]phenyl]-1-piperazinyl]phenyl]triazolones of formula CHEM wherein Q is N or CH; R is hydrogen, C1-6alkyl or arylC1-6alkyl; and R1 is hydrogen, C1-6alkyl or arylC1-6alkyl; wherein aryl is phenyl optionally substituted with up to 3 substituents each independently selected from halo, C1-6alkyl, C1-6alkyloxy and trifluoromethyl, the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, which compounds are anti-microbial agents; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.