VARIANTS OF BOVINE PANCREATIC TRYPSIN INHIBITOR PRODUCED BY RECOMBINANT DNA TECHNOLOGY, PROCESS, EXPRESSION VECTOR AND RECOMBINANT HOST THEREFOR AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Peptides essentially with the sequence of pancreatic bovine trypsin inhibitor (aprotinin) in which one or more amino acids in positions 15, 16, 17, 18, 34, 39 and 52 have been replaced by a naturally occurring amino acid are prepared by recombinant DNA technology. Also described are processes, expression vectors and recombinant hosts and the pharmaceutical use of the variants.