Process for the preparation of (methyl 4,5,6r, 8R) - 9 - 11 15 oxo Alpha, alpha - dihydroxy - 16 - 17,18,19,20 tetranorprosta 4,5,13 - phenoxy - (e) - trienoato, Crystalline

摘要

This invention relates to a process for making an enantiomer or racemic mixture of a compound of the formula IMAGE wherein R is hydrogen, lower alkyl or a pharmaceutically acceptable, non-toxic salt of a compound wherein R is hydrogen; X is hydrogen, halo, trifluoromethyl, lower alkyl or lower alkoxy, and the wavy lines represent the alpha or beta configuration with the proviso that when one wavy line is a alpha the other is beta ; novel intermediates useful for preparing these compounds; and processes for making the intermediates.