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2,6 di (amino acetylamino) benzo (1,2 - 5.4 - d; d) dithiazolen, methods for the preparation thereof and pharmaceutical preparationwith anti arthritiswerking that one or more of these compounds as active ingredient.
2,6 di (amino acetylamino) benzo (1,2 - 5.4 - d; d) dithiazolen, methods for the preparation thereof and pharmaceutical preparationwith anti arthritiswerking that one or more of these compounds as active ingredient.
Compounds of the formula IMAGE wherein R1 and R1', which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 2 carbon atoms; R2 and R2', which may be identical to or different from each other, are each hydrogen or IMAGE but other than both hydrogen at the same time, where A is alkylene of 1 to 2 carbon atoms, R5 is hydrogen, lower alkyl, lower alkylamino-lower alkyl, lower alkoxy-lower alkyl, hydroxycarbonyl-lower alkyl, cycloalkyl of 5 to 8 carbon atoms, lower alkyl-cycloalkyl of 5 to 8 carbon atoms, phenyl or morpholino; R6 is hydrogen, lower alkyl, lower alkylamino-lower alkyl or lower alkoxy-lower alkyl; or R5 and R6, together with each other and the nitrogen atom to which they are attached, form a 5-, 6- or 7-membered heterocyclic ring, where a 5- or 6-membered ring may comprise an additional sulfur or nitrogen heteroatom, and in the latter case said heterocyclic ring may optionally have one or two lower alkyl substituents, a lower alkoxy-carbonyl, a lower alkoxy-carbonyl-methyl, a hydroxy-lower alkyl, a trifluoroethyl, a cycloalkyl, a lower alkyl-cycloalkyl, a cyclohexylmethyl, a benzyl, a pyridyl, a piperidino, a phenyl, a fluoro-phenyl, a chloro-phenyl, a trifluoromethyl-phenyl, or an acetyl-phenyl substituent attached thereto; and R3 and R4, which may be identical to or different from each other, are each hydrogen, chlorine, bromine, lower alkyl, lower alkoxy, lower alkanoyl, hydroxycarbonyl, lower alkoxy-carbonyl, amino-carbonyl, phenyl, trifluoromethyl, nitro, cyano or amino; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as antiarthritics and antirheumatics.
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机译:式的化合物,其中R 1和R 1'彼此相同或不同,分别为氢或1-2个碳原子的烷基; R 2和R 2'可以彼此相同或不同,分别为氢或,但同时不是两个氢,其中A为具有1-2个碳原子的亚烷基,R 5为氢,低级烷基,低级烷基氨基-低级烷基,低级烷氧基-低级烷基,羟羰基-低级烷基,5至8个碳原子的环烷基,5至8个碳原子的低级烷基-环烷基,苯基或吗啉代; R6是氢,低级烷基,低级烷基氨基-低级烷基或低级烷氧基-低级烷基; R 5和R 6彼此之间以及与它们连接的氮原子一起形成5元,6元或7元杂环,其中5元或6元环可以包含另外的硫或氮杂原子,并且在后一种情况下,所述杂环可任选具有一个或两个低级烷基取代基,低级烷氧基-羰基,低级烷氧基-羰基-甲基,羟基-低级烷基,三氟乙基,环烷基,低级烷基-环烷基;环己基甲基,苄基,吡啶基,哌啶子基,苯基,氟代苯基,氯代苯基,三氟甲基-苯基或乙酰基-苯基取代基; R 3和R 4彼此相同或不同,分别为氢,氯,溴,低级烷基,低级烷氧基,低级烷酰基,羟羰基,低级烷氧基羰基,氨基羰基,苯基,三氟甲基,硝基,氰基或氨基;及其无毒的药理学上可接受的酸加成盐。所述化合物以及盐可用作抗关节炎药和抗风湿药。
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