4 - amino - 2 - (piperazin - 1-yl or homopiperazin - 1-yl) chinazolinen and method for preparation of this compound and method for preparation of pharmaceutical preparations underthese compounds

摘要

The invention relates to new quinazoline derivatives of the formula (I) wherein (R)n represents 6,7-di(lower alkoxy) or 6,7,8-tri(lower alkoxy); m is 1 or 2; X represents -CHR1- or -CH2CH2-; each R1, which may be the same or different, represents hydrogen or lower alkyl; and R2 and R3, which may be the same or different, each represent hydrogen, lower alkyl, lower alkoxy, halogen, lower alkanoyl, lower alkoxycarbonyl or a group of the formula-CONR4R5 or -SO2NR4R5 wherein R4 and R5, which may be the same or different, each represent hydrogen or lower alkyl; and the pharmaceutically acceptable acid addition salts thereof. Two processes for preparing these derivatives are also described. The new quinazolines are useful as regulators of the cardiovascular system, in particular for the treatment of hypertension.