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The compound, analogos tri Arg proinsulina, proinsulina cleaved, pharmaceutical formulation and process for the preparation of a analogo tri Arg insulin human.
The compound, analogos tri Arg proinsulina, proinsulina cleaved, pharmaceutical formulation and process for the preparation of a analogo tri Arg insulin human.
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机译:化合物,类似物三精氨酸胰岛素原,经胰岛素原裂解的药物制剂和制备类似物三精氨酸胰岛素人的方法。
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摘要
This invention relates to human insulin analogs (tri-arg insulins) and includes two enzymatic methods for producing tri-arg insulins. These compounds can be formulated as a soluble entity up to pH 6.1 and have prolonged hypoglycemic activity. Tri-arg insulins have the basic structure of natural human insulin plus three additional arginine residues. Two of the three additional Arg residues are located in tandem at the carboxy terminus of the insulin B-chain, and the third Arg residue is located at the amino terminus of the insulin A-chain. Tri-arg insulin analogs, having certain amino acid substitutions at the B3, B10 and A21 positions, are within the instant invention.
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