TETRAAZACYCLODODECANE DERIVATIVES CONTAINING A LINKER/SPACER MOIETY CAPABLE OF FORMING ANTIBODY CONJUGATES; COMPLEXES WITH RADIONUCLIDES AND CONJUGATES OF SUCH COMPOUNDS AND COMPLEXES WITH ANTIBODIES OR ANTIBODY FRAGMENTS

摘要

A group of functionalized polyaminocarboxylate chelants that form complexes with rare earth-type metal ions are disclosed. The complexes can be covalently attached to an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes.