PLASMODIUM CS PROTEIN ANALOGUES LACKING ONE OR MORE OF THE REPEAT EPITOPES, AND CONTAINING AT LEAST ONE NONREPEAT FLANKING EPITOPE

摘要

Recombinant immunogenic analogs of Plasmodium circumsporozoite (CS) proteins useful as malaria subunit vaccines which lack one or more of the repeat epitopes of the native CS protein but have at least one nonrepeat flanking epitope from each of the amino terminal and carboxy terminal flanking regions of the native CS protein.