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DNA CLUSTER ENCODING THE BIOSYNTHETIC PATHWAY OF TETRACYCLINE AND CHLORTETRACYCLINE
DNA CLUSTER ENCODING THE BIOSYNTHETIC PATHWAY OF TETRACYCLINE AND CHLORTETRACYCLINE
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机译:编码四环素和氯四环素的生物合成途径的DNA簇
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摘要
The present invention relates to the cloning, isolation and DNA (isolated fragment from Streptomyces aureofaciens) which directs the synthesis of tetracycline and chlortetracycline, in a heterologous host such as Streptomyces lividans. The claimed plasmids are isolated by screening a cosmid library, constructed in Escherichia coli, for the expression of tetracycline resistance in S. lividans.
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