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Process for the preparation of a controlled porosity osmotic pump for controlled release of Diltiazem L-malate and osmotic pump thus obtained
Process for the preparation of a controlled porosity osmotic pump for controlled release of Diltiazem L-malate and osmotic pump thus obtained
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机译:制备用于控制释放苹果酸地尔硫卓L-苹果酸盐的控制孔隙度的渗透泵的方法和由此获得的渗透泵
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摘要
The instant invention is directed to an osmotic pump, for the controlled release of diltiazem L-malate to an environment of use, said pump comprising: (A) a core which comprises a therapeutically effective amount of diltiazem L-malate and an effective buffering amount of sodium bitartrate surrounded by (B) a rate controlling water insoluble wall, having a fluid permeability of 6.96 x 10-18 to 6.96 x 10-14 cm3 sec/g and a reflection coefficient of less than 0.5, prepared from: (i) a polymer permeable to water but impermeable to solute and (ii) 0.1 to 60% by weight, based on the total weight of (i) and (ii), of at least one pH insensitive pore forming additive dispersed throughout said wall. The instant invention is also directed to a multiparticulate osmotic pump, for the controlled release of diltiazem L-malate to an environment of use, said pump comprising: (I) a carrier medium which does not maintain its integrity in the environment of use; and (II) a multiple of tiny osmotic pump elements, as described above.
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机译:本发明涉及一种渗透泵,用于将苹果酸地尔硫卓控制释放到使用环境中,所述泵包括:(A)核心,其包含治疗有效量的苹果酸地尔硫卓和有效缓冲量。 (B)的速率控制水不溶性壁包围的酒石酸氢钠的渗透速率为6.96 x 10 -1 1 8至6.96 x 10 -1 4 cm 3秒/ g,反射系数小于0.5,由以下因素制得:(i)透水但对溶质不透的聚合物和(ii)0.1至60%(重量),基于(i)和(ii)的总重量至少一种pH不敏感的成孔添加剂分散在整个所述壁中。本发明还涉及一种多颗粒渗透泵,用于将苹果酸地尔硫卓受控释放到使用环境中,所述泵包括:(I)在使用环境中不能保持其完整性的载体介质; (II)如上所述的多个微小的渗透泵元件。
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