A RECOMBINANT MAREK''S DISEASE VIRUS AND A VACCINE.

摘要

THERE IS PROVIDED A RECOMBINANT MAREK'S DISEASE VIRUS COMPRISING THE GENOMIC DNA OF AN ATTENUATED MAREK'S DISEASE VIRUS AND A FOREIGN GENE FROM ANOTHER SOURCE. THE PRESENT RECOMBINANT VIRUS CAN ADVANTAGEOUSLY BE USED AS AN ACTIVE INGREDIENT FOR A MULTIFUNCTIONAL LIVE VACCINE, EXHIBITING NOT ONLY THE ANTIGENICITY AND IMMUNOGENICITY OF THE MAREK'S DISEASE VIRUS BUT ALSO THE PROPERTIES ASCRIBED TO THE FOREIGN GENE. SINCE THE SUITABLE HOST CELL FOR THE RECOMBINANT VIRUS OF THE PRESENT INVENTION IS AN AVIAN CELL WHICH IS AVAILABLE IN A LARGE QUANTITY AND NOT EXPENSIVE, THE RECOMBINANT VIRUS OF THE PRESENT INVENTION CAN BE PRODUCED EFFICIENTLY AT LOW COST ON A COMMERCIAL SCALE.