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derivatives of decaidro - 8h - isochino / 2, 1 g / 1, 6 / naftiridina and decaidrobenzo / / small / 2 -, 3 - and / chinolizina.
derivatives of decaidro - 8h - isochino / 2, 1 g / 1, 6 / naftiridina and decaidrobenzo / / small / 2 -, 3 - and / chinolizina.
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机译:decaidro的衍生物-8h-异狄奇诺 / 2,1 g / 1,6 / naftiridina和decaidrobenzo / / small / 2-,3-和chinolizina。
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摘要
Compounds of the formula CHEM wherein: X and Y are independently hydrogen; hydroxy; lower alkyl of 1-6 carbon atoms; lower alkoxy of 1-6 carbon atoms; or halo; or X and Y when adjacent and taken together are methylenedioxy or ethylene-1,2-dioxy; R is lower alkyl of 1-6 carbon atoms; cycloalkyl of 3-8 carbon atoms; phenyl or phenyl lower alkyl in which any phenyl group may be optionally substituted by one or two substituents chosen from the group consisting of halo, lower alkyl of 1-4 carbon atoms and lower alkoxy of 1-4 carbon atoms; or -ANHSO2R1; wherein A is lower alkylene of 1-6 carbon atoms; and R1 is lower alkyl of 1-6 carbon atoms or -NR2R3; wherein R2 and R3 are independently hydrogen or lower alkyl of 1-6 carbon atoms, or R2 and R3 taken together are cycloalkyl of 3-8 carbon atoms; and n is 1 or 2; and the pharmaceutically acceptable salts thereof, are useful as alpha 2-adrenoceptor antagonists, in particular as peripherally selective alpha 2 -adrenoceptor antagonists.
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机译:式的化合物,其中:X和Y独立地是氢;羟基1-6个碳原子的低级烷基; 1-6个碳原子的低级烷氧基;或光环当相邻时,X和Y是亚甲基二氧基或亚乙基1,2-二氧基;或R是1-6个碳原子的低级烷基; 3-8个碳原子的环烷基;苯基或苯基低级烷基,其中任何苯基可以任选地被一个或两个选自卤素,1-4个碳原子的低级烷基和1-4个碳原子的低级烷氧基的取代基取代;或-ANHSO2R <1>;其中A是1-6个碳原子的低级亚烷基; R 1为碳数1〜6的低级烷基或-NR 2 R 3;其中R 2和R 3独立地为氢或1-6个碳原子的低级烷基,或R 2和R 3一起为3-8个碳原子的环烷基; n为1或2;及其药学上可接受的盐可用作α2-肾上腺素受体拮抗剂,特别是用作外周选择性α2-肾上腺素受体拮抗剂。
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