stereospezifisches procedure for the manufacture of enantiomers of furo replaced: 3 - 3.4 - c) pyridins, enantiomers or mixtures thereof, as well as the received the therapeutic resources

摘要

The present invention relates to stereospecific processes for the preparation of enantiomers of 3-substituted-furo[3,4-c]pyridine of formula I, wherein R3, R4 and R6 stand for various substituents, comprising the steps of: oxidation of a racemic pyridine derivative of formula II, reduction of the resulting ketone with a reducing agent, sterospecific locking or blocking of the OH group of the enantiomer alcohol, opening of the acetonide ring and cyclization of the resulting compound. IMAGE I IMAGE II The present invention also relates to compounds thus obtained and therapeutical compositions thereof.