2-guanidino-4-arylthiazoles for the treatment of peptic ulcers.

摘要

Compounds 2-guanidino-4-arylthiazole of formula (I) acid addition salt or a cationic pharmaceutically acceptable salt thereof, wherein R1 is hydrogen, (C1-C10) Alkyl, optionally substituted phenyl or optionally substituted aralkyl certain groups; R2 is hydrogen or (C1-C4) Alkyl and Ar CERTAIN CERTAIN GROUPS pyrrolyl or indolyl optionally substituted METHOD FOR USE IN THE TREATMENT OF ULCERS GASTRIC BY INHIBITING CELL PARIETAL H + / K + ATPase and antiinflammatory CONDITIONS IN CONJUNCTION WITH piroxicam for use in mammals, and in pharmaceutical compositions containing such compounds.