ABSTRACT OF THE DISCLOSURETRANSGENIC ANIMALS INCORPORATINGEXOGENOUS GROWTH HORMONE RELEASING FACTOR (GRF) GENESTransgenic animals are produced having an exogenousGRF-encoding gene inserted in their genome. The preferredgene includes a GRF-encoding sequence portion operably linkedto a strong promoter, such as the metallothionein promoter,and the preferred GRF-encoding sequence portion is a fusionof natural gene sequences and cDNA sequences. The GRF-encoding gene is microinjected into fertilized eggs whichthen incorporate the gene into their genome, and thefertilized eggs are implanted into host mothers. The animalsthat are born as a result are tested to determine whether theexogenous gene is incorporated and expressed. The transgenicanimals grow to larger than normal size. Both male andfemale transgenic animals are fertile, whereby the animalsare useful for breeding to establish fast-growing, enlargedanimal lines.
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