ANTI-ENDOTOXIN COMPOUNDS AND RELATED MOLECULES ANDANTI-ENDOTOXIN COMPOUNDS AND RELATED MOLECULES AND METHODS METHODS

摘要

ANTI-ENDOTOXIN COMPOUNDS AND RELATED MOLECULES AND METHODS Disclosed are lipid A analogs useful for the treatment of septic shock and LPS-mediated activation of viral infection. The lipid A analogs described herein provide useful therapeutics for the treatment or prevention of any LPS-mediated disorder. Such disorders include without limitation: endotoxemia (or sepsis syndrome) resulting from a Gram bacteremia (with its accompanying symptoms of fever, generalized inflammation, disseminated intravascular coagulation, hypotension, acute renal failure, acute respiratory distress syndrome, hepatocellular destruction, and/or cardiac failure); and LPS-mediated exacerbation of latent or active viral infections (e.g., infection with HIV-1, cytomegaloviruses, herpes simplex viruses, and influenza virus). The lipid A analog is typically administered in a pharmaceutically-acceptable formulation, e.g., dissolved in physiological saline or physiological saline which may include 5% glucose (for the purpose of increased analog solubility). Adminstration is by any appropriate route, but, ordinarily, it will be administered intravenously, either by intravenous injection or transfusion. When the lipid A analog is provided for the treatment of a viral infection, it may be administered in conjunction with appropriate viricidal agents. The lipid A analogs may be stored as a freeze-dried formulation.