A SIMPLIFIED METHOD FOR THE PRODUUCTION OF VINYL GLYCINE (2-AMINOBUT-3-ENIOC ACID) AND A CONVENIENT RESOLUTION OF A DERIVATIVE

摘要

HOE 92/F 055 A Simplified Method for the Production of Vinyl Glycine (2-Aminobut-3-enioc Acid) and a Convenient Resolution of a Derivative The invention relates to a three-step synthesis of vinyl glyoine (1) using a cheap, commercially available starting material (3-butenenitrile (2)) and using cheap, simple reagents. Also disclosed is a convenient optical resolution of the Ntert.butyloxycarbonyl derivative by papain-catalysed enantioselective esterification in a two-phase system.