NEW SUBSTITUTED 16-METHYL STEROID DERIVATIVES OF PREGNA-1,4-DIENE-3,20-DIONE, THEIR PREPARATION, THEIR USE IN THE PREPARATION OF 16-METHYLENE STEROIDS AND NEW INTERMEDIATES

摘要

The invention relates to the compounds (I): …IMAGE… where R is methyl or free or protected -CH2OH, R1 and R'1 are methyl; branched alkyl (5 to 8 carbon atoms), aryl (up to 10 carbon atoms), heteroaryl or benzyl, n and m are 0 or 1, R2 and R3 are hydrogen or R2 is fluorine and R3 is formyloxy or acetyloxy and the dotted lines symbolise a possible bond, to their preparation from a delta-16(17) compound, to their application to the preparation of 16-methylene derivatives and to new intermediates.