首页>
外国专利>
REGIOSELECTIVE SYNTHESIS OF 1,5-DIARYLPYRAZOLE ANTI-INFLAMMATORY AGENTS
REGIOSELECTIVE SYNTHESIS OF 1,5-DIARYLPYRAZOLE ANTI-INFLAMMATORY AGENTS
展开▼
机译:1,5-二芳基唑抗炎剂的区域选择性合成
展开▼
页面导航
摘要
著录项
相似文献
摘要
The invention provides a process for preparing 1,5-diaryl pyrazole anti-inflammatory agents. A 6-aryl-4,6-dioxohexanoic acid is treated with acetic anhydride or acetyl chloride to produce an enol lactone, which is added to methylhydroxylamine to generate the dione hydroxamic acid. This dione hydroxamic acid is then treated with 4-methoxyphenylhydrazine hydrochloride to yield the 1,5-diaryl pyrazole. Novel intermediate compounds in the synthetic pathway are also disclosed.
展开▼