Novel gene therapies employing antisense constructs

摘要

Modulation of the growth of cells is accomplished by contacting the cells with a vector capable of carrying genetic material into the cells. The genetic material codes for a nucleolar antigen or is antisense to genetic material coding for a nucleolar antigen. Portions of such genetic material, less than the whole, are also effective in certain preferred embodiments. In accordance with preferred embodiments, antisense genetic material, preferably cDNA, to that coding for p120 is used to inhibit growth of human breast carcinoma cells.