SEROTININ REUPTAKE INHIBITORS FOR S.P.E.C.T IMAGING

摘要

Disclosed are novel compounds for CNS neurotransmitter systems, especially for the neurotransmitter serotonin, which have formula (I), where each of U, V, W, X, Y and Z is independently selected from the group consisting of hydrogen; halogen; C1-C4 alkyl; C1-C4 alkyl substituted with one ore more moieties selected from halogen atoms and hydroxy groups; C1-C4 alkoxy; C1-C4 alkoxy substituted with one ore more moieties selected from halogen atoms and hydroxy groups; C1-C6 heterocycles; C1-C4 thioalkyl; NR3R4; -R5-A-R6; and -A-R7; CN; SO2R8; -NHCONH2; and C(O)NR3R4; each of R1, R2, R3 and R4 is independently selected from the group consisting of hydrogen and C1-C4 alkyl; each of R5 and R6 is independently a C1-C6 alkyl; R7 is selected from the group consisting of H, C1-C6 alkyl, C1-C6 heterocycles or -A-R5; R8 is selected from the group consisting of C1-C4 alkyl and NR3R4; A is selected from the group consisting of S, N and O; provided that at least one of U, V, W, X, Y and Z is a halogen atom; and pharmaceutically acceptable salts thereof.