TRANSGENIC MHC CLASS I AND CLASS II ANTIGEN-DEFICIENT MAMMALS

摘要

Disclosed are transgenic non-human mammals, the surface of whose cells are deficient in all MHC class II antigens and one or more MHC class I antigens. Also disclosed are the use of mammals as a model system for MHC antigen immunodeficiencies and as a source of universal donor tissue for transplant or somatic cell therapy.