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Procedure for the inversion of the stereochemistry at C13 of avermectin aglycone compounds
Procedure for the inversion of the stereochemistry at C13 of avermectin aglycone compounds
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机译:阿维菌素糖苷配基化合物在C13处的立体化学转化步骤
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摘要
The natural stereochemistry at the 13-position of avermectin aglycones, normally α-oriented or below the plane of the molecule, is inverted or epimerized into the β-position. The procedure starts with the avermectin aglycone compounds where the 13α-hydroxy group is substituted with a leaving group. Treatment of the substituted compound with tetra alkyl ammonium nitrate displaces the leaving group, substitutes a nitrate ester or a nitrooxy group, for the hydroxy and inverts the 13-stereochemistry to β. Reduction of the nitrooxy group returns the 13-hydroxy group and retains the 13-β configuration. The intermediate 13-nitrooxy compounds are themselves potent anti-parasitic agents.
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