Method and system for three-dimensional tomography of activity and connectivity of brain and heart electromagnetic waves generators

摘要

A method and system for the localization and characterization of the generators of human brain electromagnetic physiological activity includes a set bioelectromagnetic amplifiers (2), sensorial stimulators (4), and a computer based system (12) for signal analog to digital conversion and recording. Sufficient statistics (13), including higher order statistical moments, for event related components are computed from the recorded signals, either in the time, frequency, or time-frequency domain, retaining stationary, non-stationary, linear, and non-linear information. The localizations, orientations, activities, and connectivities of the generators are obtained by solving the inverse problem using sufficient statistics under anatomical and functional constraints. Realistic head geometry and conductivity profile are used to transform the measurements into infinite homogeneous medium measurements, by means of an anatomical deconvolution operator, thus simplifying optimally inverse solution computations. Goodness of fit tests (16) for the inverse solution are provided. Generator characteristics are visually displayed (18) in the form of three and two dimensional head images, and optionally include probability scaled images obtained by comparing estimated generator characteristics with those of a normal population sampled and stored in a normative data base.