Inhibition of tumor cell metastasis potential and invasiveness by chemically-defined oligosaccharides, their derivatives, mimetics and antibodies directed to them

摘要

Methods and compositions for inhibiting metastasis potential of tumor cells are provided. Metastasis potential of tumor cells may be inhibited by an agent selected from the group consisting of mimetics of monosialosyl-Lea I, monosialosyl-Lea II, disialosyl-Lea, and sialosyl Lex, the agent inhibiting the metastasis potential of the preparation. The present invention also discloses conjugates comprising the agent and poly(ethylene glycol). Methods for inhibiting GMP-140-mediated or ELAM-1-mediated cell aggregation or adhesion are also provided. The aggregation or adhesion at a tumor site can be inhibited by an agent selected from the group consisting of mimetics of monosialosyl-Lea I, monosialosyl-Lea II, disialosyl-Lea, and sialosyl Lex, the agent inhibiting the cell aggregation or adhesion.