Treatment of lyso paf-mediated diseases with paf antagonists and procedure for determining their efficacy

摘要

The invention refers to the treatment of lyso - paf - mediated diseases with paf antagonists and a procedure for determining their efficacy. According to the invention for treating a disease caused by lyso paf ( 1 - 0 - alkyl - sn - glyceryl - 3 - phosphocholine) as the precursor and metabolit of paf is found in elevated amounts in the liquor of mental and/or inflammatory diseases. Lyso paf regulates via its own receptor the paf receptors on human neutrophils which are then inhibited by paf antagonists. According to the invention for treating a mental and/or inflammatory diseases caused by lyso paf an effective amount of at least one paf antagonist is administered to a subject requiring said treatment, wherein the paf antagonist is a hydrophilic or non - hydrophilic triazolothieno - diazepine or a homologue thereof, a ginkgolide, a ginkgolide mixture or a synthetic ginkgolide derivate, or an analogue of the paf or a mixture with/of these compounds.