Process for the preparation of N-substituted lactams by reductive amination of dicarboxylic acid derivatives with mixtures of primary, secondary and tertiary amines

摘要

Process for the preparation of N-substituted lactams of the general formula I …IMAGE… in which… Z represents a C2- to C10-alkylene group, a C7- to C12-aralkylene group or a phenylene or naphthylene group and R1 represents a C1- to C20-alkyl group, a C6- to C10-aryl group or a C7- to C12-aralkyl group, by subjecting a compound of the general formula II …IMAGE… to a hydrogenation reaction with an amine in which W represents a C2- to C10-alkylene group, a C2- to C10-alkenylene group, a C7- to C12-aralkylene group or a phenylene or naphthylene group and in which the groups X and Y together form an oxa or imino bridge of the formula …IMAGE… or, alternatively, are identical or different and represent a hydroxyl group, a C1- to C20-alkoxy group, a C6- to C10-aryloxy group or a C7- to C12-aralkoxy group and in which, if X and Y are different, Y in addition to the abovementioned meanings also has the meaning of hydrogen, at elevated pressure and at elevated temperature in the presence of a catalyst, using secondary and/or tertiary amines of the formula III… NHnR13-n(III in which the radical R1 has the abovementioned meaning and the index n represents O or 1, or mixtures of these secondary and/or tertiary amines, with a primary amine of the formula IV… R1-NH2(IX as starting materials and carrying out the reaction with an addition of water and/or ammonia.