Polyester type polyfunctional macromonomer, gel and drug release controlling material responsive to changes in temperature

摘要

A polyester type polyfunctional macromonomer represented by the general formula (I): wherein R¹ represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms, X represents a hydrogen atom, a halogen atom, a cyano group, an alkyl group having from 1 to 6 carbon atoms or a phenyl group, A represents an aliphatic polyester chain, m is 0 or 1, and p, which may be the same or different in each branched chains, represents an integer of from 0 to 6; a polyester type gel which is obtained by polymerization of the polyester type polyfunctional macromonomer; and a drug release controlling material responsive to changes in temperature comprising the polyester type gel are disclosed. The polyester type gel possesses mechanical properties suitable to various utilities, in particular, as a biodegradable polymeric material having a high tensile elongation. The drug release controlling material has an on-off control function of drug release responsive to changes in temperature depending upon the gel transition of the aliphatic polyester type gel.