the 28kd proteingruppe antigenisches peptide.mansoni and procedure for isolating monoclonal antikoerper,the at least one epitope of this peptide and uses for the induction of the synthesis of neutralising antikoerpern.

摘要

Peptide fragments isolated from the S. mansoni 28 KD protein by controlled proteolysis. Process for the isolation of a peptide bearing at least one epitope, by proteolysis of the S. mansoni 28 KD protein with V8 protease, the proteolysis then being stopped in order to collect, after heating to 100 DEG C, a peptide whose antigenic activity is verified using the antibodies of a polyclonal serum or monoclonal antibodies. Use in the preparation of vaccinating compositions against S. mansoni.