METHOD FOR THE STEREOSELECTIVE PRODUCTION OF GAL- (ALPHA) (1-3) / GAL- (BETA) (1-4) / GLCNAC-TRISACCHARIDES AND NEW (BETA) (1-3) -Linked OLIGOLACTOSAMINES OVER NEW PARTIAL ALKYLATED GLY

摘要

The invention relates to a method for the stereoselective preparation of Gal- alpha (1-3)/Gal- beta (1-4)/GlcNac trisaccharides of the formula IMAGE and of beta (1-3)-linked oligolactosamines of the formula IMAGE via partially alkylated glycals of the formula IMAGE and other intermediates, in which, depending on the formula R is H, R'CH2-, allyl R1 is H, R'CH2-, allyl or R'CO-, R' is H, C1 to C3-alkyl or (un)substituted phenyl, S is a spacer, preferably of the formula -(CH2)n-COOR", R" is alkyl with 1 to 4 C atoms, X is N3 or -NHCOCH3, Y is ss-OSiR23 or alpha -OC(=NH)CCl3, R2 is C1 to C4-alkyl or phenyl, and m,n are an integer from 1 to 4 or 4 to 12 respectively.