首页> 外国专利> A method for the production of staerkeestern for clinical, especially parenteral use

A method for the production of staerkeestern for clinical, especially parenteral use

机译:生产用于临床特别是肠胃外用途的甾烷酮的方法

摘要

In order to prepare physiologically tolerated water-soluble starch esters, the invention proposes that starch is converted by acid hydrolysis or enzymatic hydrolysis to a partially hydrolysed form with a mean molecular weight in the range from 10,000 to 500,000 Daltons. This partial hydrolysate is then acylated, in aqueous solution, with the anhydride or halide of an aliphatic monocarboxylic acid with 2 to 4 carbon atoms or an aliphatic dicarboxylic acid with 3 to 6 carbon atoms, or mixtures thereof, and an alkalinization agent, to give a product with a substitution ratio in the range from 0.1 to 1.0 mole/mole. Salts are removed from the resulting reaction mixture. The starch esters thus obtained are highly suited for clinical use, in particular parenteral administration and administration in the diet.
机译:为了制备生理上可耐受的水溶性淀粉酯,本发明提出通过酸水解或酶水解将淀粉转化为平均分子量为10,000至500,000道尔顿的部分水解的形式。然后将该部分水解产物在水溶液中用具有2-4个碳原子的脂族单羧酸或具有3-6个碳原子的脂族二羧酸或它们的混合物的酸酐或卤化物和碱化剂酰化,得到取代比为0.1至1.0摩尔/摩尔的产物。从所得反应混合物中除去盐。由此获得的淀粉酯高度适合于临床使用,特别是肠胃外给药和饮食中的给药。

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号