A cardioplegia administration set including a heat exchanger, a bubble trap, a three-end connector, a normally-closed, pressure-responsive valve and interconnecting tubing. A first tubing means having an inlet adapted to be connected to a source of cardioplegia solution and an outlet connected to an inlet of the three-end connector interconnects inlets and outlets of the heat exchanger and the bubble trap therebetween so that a solution passageway is established from the source of cardioplegia solution through the heat exchanger and the bubble trap to an end of the three-end connector adapted to connect to an injection catheter. A second tubing means has an inlet connected to the recirculation outlet of the three-end connector and an outlet adapted to be connected to the source of cardioplegia solution so that a solution passageway is established from the three-end connector through the normally-closed valve back to the source of cardioplegia solution when the valve is open. The second tubing means and the normally-closed, pressure-responsive valve together comprise a recirculation loop.
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