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Benzheterocyclyl sulphones

机译:Benz hetero采用成立以来塑料phones

摘要

The invention concerns novel, pharmaceutically useful, benzheterocyclyl sulphones of the formula I: ##STR1## in which ring A may bear optional halogeno, (1-4C)alkyl or fluoro(1-4C)alkyl substituents; X is oxygen, or a group of the formula --S(O).sub.n -- or --NR.sup.1 -- in which n is zero, 1 or 2 and R.sup.1 is hydrogen, (1-4C)alkyl, (1-6C) alkanoyl, benzoyl or phenyl(1-4C)alkyl, the last two optionally substituted; Y is various linking groups defined hereinafter, such as ethylene or trimethylene; and in which the group --SO.sub.2 CH.sub.2 NO. sub.2 is located at position a, b or c in ring A; together with the non- toxic thereof. Other aspects of the invention include the production of the novel compounds by analogy processes and pharmaceutical compositions of the novel compounds for use in the treatment of diabetic complications.
机译:本发明涉及式I的新型可药用的苯并杂环基砜:其中环A可带有任选的卤素,(1-4C)烷基或氟(1-4C)烷基取代基; X是氧,或式--S(​​O)n-或--NR.sup.1的基团,其中n为零,1或2,而R.sup.1是氢, (1-4C)烷基,(1-6C)烷酰基,苯甲酰基或苯基(1-4C)烷基,最后两个任选被取代; Y是下文定义的各种连接基团,例如亚乙基或三亚甲基;并且其中--SO.sub.2 CH.sub.2 NO。 sub.2位于环A的a,b或c位置;以及其无毒。本发明的其他方面包括通过类比方法生产新化合物以及用于治疗糖尿病并发症的新化合物的药物组合物。

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