Syntheses of optically pure amp;agr;-amino acids from 3-amino-2- oxetanone salts

摘要

A process for the preparation of optically pure &agr;-amino acids comprising the nucleophilic ring-opening of 3-amino-2-oxetanone salts. N- Protected serine &bgr;-lactones are deprotected to form heretofore unknown 3-amino-2-oxetanone and its corresponding salts. In turn these previously unknown 3-amino-2-oxetanone salts may be used in the synthesis of other novel or rare stereochemically-pure free amino acids.