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Certain phosphonic acid quinoline-2-carboxylic acids, esters or amides useful for treatment of disorders responsive to N-methyl D- aspartate receptor blockade
Certain phosphonic acid quinoline-2-carboxylic acids, esters or amides useful for treatment of disorders responsive to N-methyl D- aspartate receptor blockade
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机译:某些膦酸喹啉-2-羧酸,酯或酰胺可用于治疗对N-甲基D-天冬氨酸受体阻滞剂有反应的疾病
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摘要
The present invention is that the achievable function of the phosphonic acid moiety in relation to formula phosphonic acids ##STR1## one or both of them acid hydroxy groups is in good form pharmaceutically acceptable mono- or two -ester; Wherein Y represents the 2-carboxytetrahydroquinolinyl carboxyperhydroquinolinyl or 2- optionally replaced, and wherein function pharmaceutically acceptable ester in good form or amide may be implemented in carboxyl; It is a kind of to represent one and be directly connected to key, lower alkenylene, low-carbon alkylidene or alkylidene; With its pharmaceutically acceptable sa These compounds can be used for treating mammalian nervous system imbalance and the sensitive excitatory amino acid receptors of antagonist N-methyl-D-aspartate.
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