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Biologically active material characterized by catabolic activity generally associated with cachexia-inducing tumors, preparations, production and uses thereof
Biologically active material characterized by catabolic activity generally associated with cachexia-inducing tumors, preparations, production and uses thereof
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机译:具有分解代谢活性特征的生物活性物质,通常与诱导恶病质的肿瘤有关,其制备,生产和用途
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摘要
A biologically active lipolytic factor having an average molecular weight substantially less than 5000 daltons and comprising active molecular species having molecular weights of about 3000 daltons, 1500 daltons and 700-800 daltons is disclosed. The factor can be isolated, using chromatographic methods, from cachexia-inducing tumours, cultures of tissue cells of cachexia-inducing tumours especially cultures of a MAC16 tumour cell line, or from body fluids such as serum or urine of mammals bearing cachexia-inducing tumours. Cancer diagnostic applications in relation to human individuals are described as well as uses for screening and identifying potential anti-cachetic and/or antitumour therapeutic agents.
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