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Method for the prescreening of drugs targeted to the V3 hypervariable loop of the HIV-1 envelope glycoprotein gp 120
Method for the prescreening of drugs targeted to the V3 hypervariable loop of the HIV-1 envelope glycoprotein gp 120
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机译:预筛选针对HIV-1包膜糖蛋白gp 120的V3高变环的药物的方法
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摘要
A method for the rapid screening of a drug targeted to the V3 hypervariable loop of the human immunodeficiency virus type 1 or type 2 envelope glycoprotein gp 120 comprising measuring the inhibitory effect of the drug on the interaction between gp 120 (or an antigen comprising the V3 hypervariable loop of HIV 1 gp 120 or HIV 2 gp 120) and antibodies specific for the V3 hypervariable loop, and anti-HIV chemotherapy with drugs binding to the V3 hypervariable loop.
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机译:一种快速筛选针对人免疫缺陷病毒1型或2型包膜糖蛋白gp 120的V3高变环的药物的方法,该方法包括测量药物对gp 120(或包含V3的抗原)之间相互作用的抑制作用HIV 1 gp 120或HIV 2 gp 120的高变环)和对V3高变环具有特异性的抗体,以及结合了V3高变环的药物进行的抗HIV化疗。
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