Amphetamine protein complex as immunogen for obtaining antibodies specific to methamphetamine

摘要

A N-(4-aminobutyl)amphetamine-protein complex has been synthesized to be used as an immunogen to prepare an antibody having a higher affinity to methamphetamine that to the hapten N-(4-aminobutyl) amphetamine. The antibody prepared by the use of the complex has 1,000 times the affinity to methamphetamine as that of an antibody prepeared by the use of N-(4- aminobutyl)methamphetamine-protein complex as an immunogen.