Process of preparing enantiomerically pure 1,8-bridged 4- quinolone-3- carboxylic acids

摘要

The invention relates to a process for the preparation of highly antibacterially active enantiomerically pure 1,8-bridged 4- quinolone-3- carboxylic acids and derivatives of the formula (I) ##STR1## in which 1) a compound of the formula ##STR2## is reacted with a compound of the formula ##STR3## to form a compound of the formula ##STR4## followed by cyclization to form a compound of the formula ##STR5## and further cyclization to form a compound of the formula ##STR6## an finally reaction of the cyclized product with amines of the formula ##STR7##