SYNERGISTIC COMPOSITIONS OF SOLUBLE COMPLEMENT RECEPTORS AND COMPOUNDS THAT INHIBIT COMPLEMENT AND/OR SUPPRESS IMMUNE ACTIVITY

摘要

The present invention relates to synergistic therapeutic compositions of synergistic combinations of organic and biological compounds which inhibit complement and/or possess immunosuppressive activity, and the therapeutic uses thereof. The organic compounds of the invention are compounds which exhibit immunosuppressive and/or anti-inflammatory activity. Such organic compounds include but are not limited to K-76, K-76 COOH and derivatives and synthetic analogs thereof, antimetabolites, antimitotic drugs, cyclosporine, steroids, and non-steroidal anti-inflammatory agents. In a particular aspect, the organic compounds of the invention include substituted dihydrobenzofurans, substituted and unsubstituted spirobenzofuran-2(3H)-cycloalkanes, and their open chain intermediates which exhibit such inhibitory ativities. The biological compounds of the invention are complement receptors or fragments thereof and soluble members of the complement receptor family that contain the conserved SCR motif and that are able to inhibit complement activity. The biological compounds exhibit at least one of the functions associated with complement receptors and/or SCR containing proteins. The invention relates to the use of mixtures of these compounds for therapy of immune and/or inflammatory disorders.