New anticancer property antibiotic rezoruchiomaishin and its manufacturing method

摘要

PURPOSE:To prepare resorthiomycin having an antitumor property by culturing a resorthiomycin-producing bacterium belonging to the genus Streptomycin in a medium containing nutritive sources. CONSTITUTION:Streptomyces collinus 45H-6 strain (FERM 10753) separated from a soil collected in Isehara city, Kanagawa prefecture has the following mycological properties. Figure: forms aerial mycelium and produces spores each having a size of 0.5-0.9X 0.8-1.0mum; excellently grows in a starch-inorganic salt agar medium; liquidizes gelatin; utilizes glucose and does not utilize sucrose; growth temperature: 20-40 deg.C, etc. The bacterium is cultured in a medium containing peptone, sucrose, NaCl, etc. The cultured product is subjected to an extraction and purification treatment using a solvent extraction method, an ion exchange resin method, etc., to prepare an antitumor antibiotic, resorthiomycin of the formula or a salt thereof.