13 displacement 5 ketomirubemaishin chemical compound

摘要

NEW MATERIAL:A compound expressed by formula I (R1 is methyl, ethyl, isopropyl or sec-butyl; n is 0 or 1; R2 is 1-18C straight chain, branched or cyclic alkyl which may be substituted by alkyl, alkoxy, halogen, etc.; 7-9C aralkyl, 2-6C alkenyl, 2-6C alkynyl, etc., provided that the above-mentioned alkyl, alkoxyalkyl and haloalkyl substituent groups are other than the case where R2 is alkyl, alkenyl or alkynyl). EXAMPLE:13-(p-Fluorophenoxy)acetyloxy-5-ketomilbemycin A4. USE:An insecticide, acaricide and anthelmintic agent. PREPARATION:A 13-hydroxy-5-ketomilbemycin compound expressed by formula II is reacted with a carboxylic acid expressed by formula III or a reactive derivative thereof to afford the aimed compound expressed by formula I. When the carboxylic acid is used, a dehydrating agent, e.g. dicyclohexylcarbodiimide (DCC), is preferably used.