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jihidoropirijin 5 phosphon amide Acids

机译:Jihidoro Pirijin 5 p Ho sp Hon Ami de Ashi ds

摘要

NEW MATERIAL:The compound of formula I {X1 and X2 are H, nitro, trifluoromethyl, lower alkyl, (halogen-substituted) lower alkoxy, F or Cl; R1 and R2 are H, 1-6C alkyl or R1 and R2 together form (substituted) 1,4-butylene; R3 is 1-10C alkyl or R3 and R2 together form (substituted) ethylene, etc.; Y is 1-4C alkyl, group of formula II [R5 and R6 are (substituted) 1-4C alkyl] or group of formula III} and its salt. EXAMPLE:5-(Ethoxy-N, N-dimethylamino-phosphinyl)-2,6-dimethyl-4-(3-chlorophe ny-l)--1,4-dihydropyridine-3-carboxylic acid 2-(N-benzyl-N-methylamino)-ethyl ester. USE:A remedy for circulatory diseases. PREPARATION:The compound of formula IV is made to react with the comopund of formula V.
机译:新材料:式I的化合物{X 1和X 2为H,硝基,三氟甲基,低级烷基,(卤素取代的)低级烷氧基,F或Cl; R 1和R 2为H,1-6C烷基或R 1和R 2一起形成(取代的)1,4-丁烯; R 3为1〜10C的烷基或R 3与R 2一起形成(取代的)乙烯等。 Y为1-4C烷基,式II的基团[R 5和R 6为(取代的1-4C烷基)]或式III}的基团及其盐。实施例:5-(乙氧基-N,N-二甲基氨基-膦基)-2,6-二甲基-4-(3-氯苯甲基-1-)-1,4-二氢吡啶-3-羧酸2-(N-苄基) -N-甲基氨基)-乙酯。用途:一种治疗循环系统疾病的药物。制备:使式IV的化合物与式V的化合物反应。

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