USE OF COMPLEMENT INHIBITOR TO MANUFACTURE MEDICINE FOR PREVENTION AND TREATMENT OF INFLAMMATORY INTESTINAL AND SKIN DISEASE AND PELIOSIS

摘要

PURPOSE: To provide a complement inhibitor useful as a medicine for treating and preventing of an inflammatory dermatosis, intestinal disease and purpura. CONSTITUTION: This medicine is the complement inhibitor and particularly its C1 inactivator and I factor or H factor has an action to suppress Arthus reaction. The soln. contg. such C1 inactivator and I factor or H factor is useful for prevention and treatment of the inflammatory dermatosis; for example, pustular skin disease, dermatitis group, psoriasis, intestinal disease, particularly, Chrohn's disease, tumorous colon inflammation and inflammatory purpura. The soln. allows intravenous, intramuscular or subcutaneous administration and the dosage thereof is the C1 inactivator: 1 to 500 IU/kg/day, the I factor: 0.05 to 100 mg/BW/day, the H factor: 0.005 to 100 mg/kg/BW/day. The separate administration of these inhibitors or the administration in combination thereof is possible.