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PROCEDURE FOR PREPARING A SOLUTION WITH HIGH SPECIFIC SPACIFIC ACTIVITY OF A PROTEIN WITH PLASMINOGENE ACTIVATOR (T-PA) ACTIVITY, SOLUTION CONTAINING PROTEIN WITH T-PA ACTIVITY
PROCEDURE FOR PREPARING A SOLUTION WITH HIGH SPECIFIC SPACIFIC ACTIVITY OF A PROTEIN WITH PLASMINOGENE ACTIVATOR (T-PA) ACTIVITY, SOLUTION CONTAINING PROTEIN WITH T-PA ACTIVITY
On preparation of parenteral solutions for the treatment and prophylaxis of thromboses and embolisms to date it has been necessary, because of the poor solubility of t-PA, either to infuse very large volumes or else prepare a solution with a low volume and high t-PA concentration by adjusting to a low, non-physiological pH of 2 to 5. The invention therefore relates to a process for preparing a solution of high specific volume-based activity of a protein with plasminogen activator activity, achieving an increase in stability and solubility by adding at least two substances from the group of D-and/or L-amino acids, the salts, derivatives or homologues thereof, and to a process for pasteurising a protein solution with t-PA activity and to the use of this solution as fibrinolytic in human and veterinary medicine.
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