4-arylcarbonyl-1-OE (4-morpholinyl) -lower ALKYLAA-1H-indoles process for their preparation, analgesic compositions containing such compounds and use of these compounds for the manufacture of pharmaceutical preparations for pain

摘要

4-Arylcarbonyl-1-[(4-morpholinyl)-lower-alkyl]-1H-indoles, useful as analgesic agents, are prepared by reaction of a 3-arylcarbonyl-2-methylnitrobenzene with DMF dimethyl acetal; reductive cyclization of the product with hydrogen over a catalyst; and N-alkylation of the resulting 4-arylcarbonylindole with an appropriate 4-(halo-lower-alkyl)morpholine in the presence of a strong base.